Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | POLA1 | P09884 | 2/20 | 0.37 |
| ▸ | POLG | P54098 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.37 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2160243 | 0.79 | FGFR1 (0.47) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL16020631 | 0.77 | FGFR1 (0.61) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL16020630 | 0.74 | FGFR1 (0.55) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL4945604 | 0.72 | NT5E (0.44) | POLBPOLA1 | |
| Pmedap SCHEMBL215611 | 0.72 | FGFR1 (0.72) | FGFR1SLC22A6POLBPOLA1POLG | |
| Pmedap SCHEMBL29571667 | 0.72 | FGFR1 (0.72) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL1566029 | 0.71 | FGFR1 (0.55) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL1565553 | 0.70 | FGFR1 (0.56) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL28420439 | 0.70 | FGFR1 (0.59) | FGFR1SLC22A6POLBPOLA1POLG | |
| SCHEMBL1565558 | 0.67 | FGFR1 (0.57) | FGFR1SLC22A6POLBPOLA1POLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | claimed |
| WO-2008138327-A9 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2009-12-30 | — | — | WO | disclosed |
| WO-2008138327-A2 | POLYMERASE INHIBITORS AND THE USE THEREOF FOR THE TREATMENT OF TUMORS | FREIE UNIVERSITÄT BERLIN (DE) | 2008-11-20 | — | — | WO | disclosed |
| EP-1990054-A1 | Polymerase inhibitors and their use in treating tumours | Freie Universität Berlin (DE) | 2008-11-12 | — | — | EP | disclosed |