Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944242 | 0.90 | NPC1 (0.33) | KMT2AMAPTNPC1HPGDCYP2C19 | |
| SCHEMBL4944606 | 0.89 | RAB9A (0.41) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4946212 | 0.78 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1544707 | 0.73 | MEN1 (0.40) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4944624 | 0.65 | RAB9A (0.53) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4944614 | 0.64 | KDM4E (0.34) | MEN1KMT2AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4945218 | 0.64 | ALDH1A1 (0.33) | KMT2AALDH1A1SMN1; SMN2HPGDRAB9A | |
| SCHEMBL1543704 | 0.64 | KCNH2 (0.41) | ALDH1A1MAPTNPC1HPGDRAB9A | |
| SCHEMBL4945225 | 0.64 | KMT2A (0.50) | MEN1KMT2AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4943990 | 0.62 | CYP3A4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | GRM5, GRIK5, GRM2 | MEN1 3387/4885KMT2A 2030/4885ALDH1A1 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.