Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.75 |
| ▸ | THRB | P10828 | 1/20 | 0.75 |
| ▸ | MTOR | P42345 | 1/20 | 0.75 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.75 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.75 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.60 |
| ▸ | ST6GAL1 | P15907 | 5/20 | 0.57 |
| ▸ | NT5E | P21589 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5491562 | 0.90 | LMNA (0.75) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL366600 | 0.90 | LMNA (0.75) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL14178411 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL13524621 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL158513 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL383499 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL17304691 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL2811458 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL18231346 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 | |
| SCHEMBL15338532 | 0.89 | LMNA (0.73) | LMNATHRBMTORMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4101888-B2 | — | — | 2008-06-18 | — | — | JP | claimed |
| US-20040092468-A1 | Immunostimulatory oligonucleotides with modified bases and methods of use thereof | SCHWARTZ DAVID (US) | 2004-05-13 | — | — | US | claimed |
| US-20040006034-A1 | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof | RAZ EYAL (US) | 2004-01-08 | — | — | US | claimed |
| JP-2002517156-A | — | — | 2002-06-11 | — | — | JP | claimed |
| EP-1121373-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF | Dynavax Technologies Corporation (US) | 2001-08-08 | — | — | EP | claimed |
| EP-0986572-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF | Dynavax Technologies Corporation (US) | 2000-03-22 | — | — | EP | claimed |
| WO-1999062923-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES WITH MODIFIED BASES AND METHODS OF USE THEREOF | DYNAVAX TECHNOLOGIES CORPORATION (US) | 1999-12-09 | — | — | WO | claimed |
| WO-1998055495-B1 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF | DYNAVAX TECH CORP (US) | 1999-07-22 | — | — | WO | claimed |
| WO-1998055495-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF | DYNAVAX TECHNOLOGIES CORPORATION (US) | 1998-12-10 | — | — | WO | claimed |
| US-20070027098-A1 | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof | DYNAVAX TECHNOLOGIES CORPORATION | 2007-02-01 | — | — | US | disclosed |
| US-20040006034-A1 | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof | RAZ EYAL (US) | 2004-01-08 | — | — | US | disclosed |
| EP-1374894-A2 | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof | Dynavax Technologies Corporation (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6589940-B1 | Immunostimulatory oligonucleotide compositions. These oligonucleotides comprise an immunostimulatory octanucleotide sequence. These oligonucleotides can be administered in conjunction with an immunostimulatory peptide or antigen. | DYNAVAX TECHNOLOGIES CORPORATION | 2003-07-08 | — | — | US | disclosed |
| EP-0986572-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF | Dynavax Technologies Corporation (US) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055495-A2 | IMMUNOSTIMULATORY OLIGONUCLEOTIDES, COMPOSITIONS THEREOF AND METHODS OF USE THEREOF | DYNAVAX TECHNOLOGIES CORPORATION (US) | 1998-12-10 | — | — | WO | disclosed |