Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.38 |
| ▸ | CBLB | Q13191 | 2/20 | 0.35 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4945254 | 0.89 | PSEN1 (0.43) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4948485 | 0.87 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4942219 | 0.87 | PSEN1 (0.41) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4948980 | 0.86 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4946203 | 0.85 | PSEN1 (0.38) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4943720 | 0.85 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4956783 | 0.84 | PSEN1 (0.38) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4947199 | 0.84 | MMP1 (0.44) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4963446 | 0.84 | PSEN1 (0.38) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4943615 | 0.83 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633350-A4 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1633350-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2005009344-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |