Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.36 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.36 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR2B | P41595 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2956970 | 0.91 | PSEN1 (0.40) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4945243 | 0.89 | PSEN1 (0.43) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4947202 | 0.84 | MMP1 (0.41) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL8313682 | 0.81 | PSEN1 (0.38) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL2958410 | 0.81 | PSEN1 (0.38) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL4942350 | 0.80 | MMP2 (0.42) | MMP1MMP2MMP9MMP8 | |
| SCHEMBL2968170 | 0.79 | MMP1 (0.36) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL8322329 | 0.78 | PSEN1 (0.45) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL8322384 | 0.78 | PSEN1 (0.43) | MMP1MMP2MMP9MMP8PSEN1 | |
| SCHEMBL2965388 | 0.78 | PSEN1 (0.43) | MMP1MMP2MMP9MMP8PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633350-A4 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARM INC (US) | 2008-11-26 | — | — | EP | disclosed |
| EP-1633350-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2005009344-A2 | ACYLATED AMINO ACID AMIDYL PYRAZOLES AND RELATED COMPOUNDS | ELAN PHARMACEUTICALS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |