Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096746 | 0.90 | F10 (0.49) | KCNH2THRBF10TP53TSHR | |
| SCHEMBL4947858 | 0.88 | POLB (0.36) | LMNANPC1RAB9A | |
| SCHEMBL1096380 | 0.86 | THRB (0.43) | KCNH2THRBF10TP53TSHR | |
| SCHEMBL1097104 | 0.75 | F10 (0.48) | KCNH2THRBF10TP53TSHR | |
| SCHEMBL1096743 | 0.75 | F10 (0.47) | F10LMNAKDM4ENPC1RAB9A | |
| SCHEMBL1096740 | 0.75 | F10 (0.47) | F10LMNAKDM4ENPC1RAB9A | |
| SCHEMBL1095346 | 0.75 | POLB (0.45) | F10TSHRLMNAKDM4E | |
| SCHEMBL1106532 | 0.75 | POLB (0.45) | F10TSHRLMNAKDM4E | |
| SCHEMBL1097250 | 0.74 | USP30 (0.42) | F10NPC1RAB9A | |
| SCHEMBL1098649 | 0.74 | F10 (0.48) | KCNH2THRBF10TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893572-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006002099-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | claimed |
| EP-1893572-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006002099-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |