Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4947248 | 0.88 | KCNH2 (0.43) | LMNANPC1RAB9A | |
| SCHEMBL1097250 | 0.84 | USP30 (0.42) | SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL1096746 | 0.78 | F10 (0.49) | POLBLMNAKMT2AMEN1 | |
| SCHEMBL1095346 | 0.78 | POLB (0.45) | POLBSMN1; SMN2ALDH1A1HTTJAK2 | |
| SCHEMBL1106532 | 0.78 | POLB (0.45) | POLBSMN1; SMN2ALDH1A1HTTJAK2 | |
| SCHEMBL1096412 | 0.77 | POLB (0.44) | POLBSMN1; SMN2ALDH1A1HTTJAK2 | |
| SCHEMBL1096380 | 0.73 | THRB (0.43) | SMN1; SMN2ALDH1A1LMNANPC1RAB9A | |
| SCHEMBL1096930 | 0.72 | HPGD (0.40) | — | |
| SCHEMBL1106534 | 0.72 | USP30 (0.40) | POLBSMN1; SMN2ALDH1A1HTTJAK2 | |
| SCHEMBL1096781 | 0.72 | USP30 (0.40) | POLBSMN1; SMN2ALDH1A1HTTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893572-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006002099-A2 | FACTOR XA INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-01-05 | — | — | WO | disclosed |