Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870174 | 0.81 | PARP1 (0.40) | PARP1ACHEHSD17B10MAPKAPK2ALDH1A1 | |
| SCHEMBL11701223 | 0.81 | PARP1 (0.40) | PARP1ACHEALDH1A1MEN1KMT2A | |
| SCHEMBL4947965 | 0.77 | KDM4E (0.33) | PARP1HSD17B10ALDH1A1MEN1MAPT | |
| SCHEMBL3941319 | 0.75 | ACHE (0.41) | PARP1ACHEHSD17B10ALDH1A1MEN1 | |
| SCHEMBL4941638 | 0.74 | MEN1 (0.39) | PARP1HSD17B10ALDH1A1MEN1MAPT | |
| SCHEMBL4947364 | 0.74 | PARP1 (0.36) | PARP1HSD17B10ALDH1A1MEN1MAPT | |
| SCHEMBL9396807 | 0.73 | PARP1 (0.40) | PARP1 | |
| SCHEMBL18602594 | 0.73 | PARP1 (0.36) | PARP1HSD17B10ALDH1A1MAPTTHRB | |
| SCHEMBL20898042 | 0.71 | SRC (0.38) | PARP1HSD17B10MAPKAPK2ALDH1A1CYP3A4 | |
| SCHEMBL9035419 | 0.71 | ACHE (0.46) | PARP1ACHEHSD17B10MAPKAPK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994028863-A1 | 8-AMINO-1,2,3,4-TETRAHYDROQUINOLINES AS COUPLERS IN DYES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-12-22 | — | — | WO | claimed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| US-9745299-B2 | Substituted tricyclic benzimidazoles as kinase inhibitors | SELVITA SA (PL) | 2017-08-29 | — | — | US | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
| EP-2917217-B1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S A (PL) | 2017-03-08 | — | — | EP | disclosed |
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2015-10-01 | — | — | US | disclosed |
| EP-2917217-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA S.A. (PL) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014072435-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2014-05-15 | — | — | WO | disclosed |
| WO-2014072435-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | SELVITA SA (PL) | 2014-05-15 | — | — | WO | disclosed |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | ASTRAZENECA AB (SE) | 2008-12-25 | — | — | US | disclosed |
| WO-2007018998-A2 | TRICYCLIC BENZIMIDAZOLES AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-02-15 | — | — | WO | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | US | disclosed |
| WO-1994028863-A1 | 8-AMINO-1,2,3,4-TETRAHYDROQUINOLINES AS COUPLERS IN DYES | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1994-12-22 | — | — | WO | disclosed |
| EP-0146370-B1 | IMIDAZOQUINOLINES CONTAINING OTHER HETEROCYCLIC GROUPS | JOHN WYETH & BROTHER LIMITED (GB) | 1988-10-19 | — | — | EP | disclosed |
| US-4703044-A | Imidazoquinolines containing other heterocyclic groups, useful as anti-ulcer or anti-secretory agents | JOHN WYETH & BROTHER LIMITED (GB) | 1987-10-27 | — | — | US | disclosed |
| EP-0146370-A2 | Imidazoquinolines containing other heterocyclic groups | JOHN WYETH & BROTHER LIMITED (GB) | 1985-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032469-A1 | Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators | GRM2, GRM1, GRIN2B | PARP1 4669/4885ACHE 2218/4885HSD17B10 2706/4885 |
| US-20080318999-A1 | Tricyclic Benzimidazoles and Their Use as Metabotropic Glutamate Receptor Modulators | GRM2, GRM1, GRIN2B | PARP1 4669/4885ACHE 2218/4885HSD17B10 2706/4885 |
| US-20150274726-A1 | SUBSTITUTED TRICYCLIC BENZIMIDAZOLES AS KINASE INHIBITORS | CDK8, CDK18, CDK9 | PARP1 1282/4885ACHE 3445/4885HSD17B10 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.