Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1D | Q01668 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8165968 | 0.75 | CACNA1D (0.54) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL13198586 | 0.73 | CACNA1C (0.63) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL7186078 | 0.72 | KMT2A (0.45) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL11307558 | 0.72 | ADORA3 (0.62) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL31299804 | 0.71 | ALDH1A1 (0.49) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL11442155 | 0.71 | MAPT (0.50) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL21633870 | 0.69 | CACNA1D (0.45) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL4608748 | 0.69 | CACNA1C (0.73) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL12727534 | 0.69 | CACNA1C (0.58) | CACNA1DKMT2ATDP1MAPTALDH1A1 | |
| SCHEMBL612520 | 0.69 | CACNA1C (0.73) | CACNA1DKMT2ATDP1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0184841-B1 | 1,4-DIHYDROPYRIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-11-11 | — | — | EP | claimed |
| CN-103154066-A | Kit of parts for curable coating composition | AKZO NOBEL COATINGS INT BV | 2013-06-12 | — | — | CN | disclosed |
| CN-101331165-B | Multilayer coating system | AKZO NOBEL COATINGS INT BV | 2011-11-16 | — | — | CN | disclosed |
| CN-101331165-A | Multilayer coating system | AKZO NOBEL COATINGS INT BV (NL) | 2008-12-24 | — | — | CN | disclosed |
| EP-1789464-B1 | COATING COMPOSITION BASED ON THIOL-NCO CURING | AKZO NOBEL COATINGS INT BV (NL) | 2008-11-05 | — | — | EP | disclosed |
| EP-0529702-B1 | Dihydropyridine derivatives, their preparation and their use | SANKYO CO (JP) | 1996-12-11 | — | — | EP | disclosed |
| US-5378718-A | Cardiovascular activity, hypotensive | CEDONA PHARMACEUTICALS B.V. (NL) | 1995-01-03 | — | — | US | disclosed |
| EP-0266922-B1 | DIHYDROPYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-09-08 | — | — | EP | disclosed |
| EP-0529702-A1 | Dihydropyridine derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1993-03-03 | — | — | EP | disclosed |
| WO-1992002503-A1 | NOVEL 1,4-DIHYDROPYRIDINE DERIVATIVES | CEDONA PHARMACEUTICALS BV (NL) | 1992-02-20 | — | — | WO | disclosed |
| US-4992451-A | Hypotensive agents, calcium blocking agents | SANKYO COMPANY, LIMITED (JP) | 1991-02-12 | — | — | US | disclosed |
| US-4772596-A | CALCIUM BLOCKERS | SANKYO COMPANY LIMITED (JP) | 1988-09-20 | — | — | US | disclosed |
| EP-0266922-A1 | Dihydropyridine derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-05-11 | — | — | EP | disclosed |
| EP-0249174-A1 | 1,4-dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions containing same | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1987-12-16 | — | — | EP | disclosed |
| EP-0207674-A2 | 1,4-Dihydropyridine derivatives, their preparation and their pharmaceutical use | SANKYO COMPANY LIMITED (JP) | 1987-01-07 | — | — | EP | disclosed |
| EP-0088940-B1 | PYRIDINE-CARBOXYLIC-ACID ESTERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BAYER AG (DE) | 1986-05-21 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |