SCHEMBL4947451

SCHEMBL4947451

Cc1ccc(Cl)c(OCC2CO2)c1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.54
GLA P06280 1/20 0.54
MAPT P10636 6/20 0.50
HPGD P15428 5/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
NPSR1 Q6W5P4 2/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
POLB P06746 2/20 0.50
CYP2C9 P11712 2/20 0.50
CYP2C19 P33261 2/20 0.50
USP2 O75604 1/20 0.50
ALOX12 P18054 1/20 0.50
MAPK1 P28482 1/20 0.50
TP53 P04637 3/20 0.45
TSHR P16473 3/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
HIF1A Q16665 2/20 0.45
CYP3A4 P08684 2/20 0.45
TDP1 Q9NUW8 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31213024 0.85 ALDH1A1 (0.64) ALDH1A1GLAMAPTHPGDMEN1
SCHEMBL4945160 0.85 ALDH1A1 (0.64) ALDH1A1GLAMAPTHPGDMEN1
SCHEMBL27131262 0.85 ALDH1A1 (0.59) ALDH1A1GLAMAPTHPGDL3MBTL1
SCHEMBL2337120 0.83 ALDH1A1 (0.49) ALDH1A1GLAMEN1KMT2ACYP2C9
SCHEMBL3461405 0.83 ALDH1A1 (0.50) ALDH1A1GLAMAPTHPGDMEN1
SCHEMBL262508 0.81 ALDH1A1 (0.64) ALDH1A1GLAMAPTHPGDL3MBTL1
SCHEMBL7953349 0.81 ALDH1A1 (0.64) ALDH1A1GLAMAPTHPGDL3MBTL1
SCHEMBL7953345 0.81 ALDH1A1 (0.64) ALDH1A1GLAMAPTHPGDL3MBTL1
SCHEMBL7966930 0.81 ALDH1A1 (0.54) ALDH1A1GLAMAPTHPGDL3MBTL1
SCHEMBL7966929 0.81 ALDH1A1 (0.54) ALDH1A1GLAMAPTHPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008083054-A2 LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2008-07-10 WO disclosed
WO-2008083054-A2 LIGANDS FOR CARDIAC BETA1 ADRENOCEPTOR FOR IMAGING CONGESTIVE HEART FAILURE BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) 2008-07-10 WO disclosed
US-5135932-A 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE DR. KARL THOMAE GMBH (DE) 1992-08-04 US disclosed
EP-0259835-B1 PYRIDAZINONE DERIVATIVES TEIKOKU HORMONE MFG. CO., LTD. (JP) 1992-01-15 EP disclosed
EP-0400519-A1 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them Dr. Karl Thomae GmbH (DE) 1990-12-05 EP disclosed
EP-0200915-B1 AMINOPROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AND MEDICINES CONTAINING THEM Roche Diagnostics GmbH (DE) 1989-09-27 EP disclosed
US-4863949-A CARDIOVASCULAR DISORDER TREATMENT BOEHRINGER MANNHEIM GMBH (DE) 1989-09-05 US disclosed
US-4843072-A Antihypertensive pyridazinone aminoisopropanol derivatives TEIKOKU HORMONE MFG. CO., LTD. (JP) 1989-06-27 US disclosed
EP-0259835-A2 Pyridazinone derivatives TEIKOKU HORMONE MFG. CO., LTD. (JP) 1988-03-16 EP disclosed
EP-0200915-A1 Aminopropanol derivatives, process for their preparation, their use and medicines containing them Roche Diagnostics GmbH (DE) 1986-11-12 EP disclosed
US-4599333-A HYPOTENSIVE AGENTS TEIKOKU HORMONE MFG. CO., LTD. (JP) 1986-07-08 US disclosed
EP-0097202-A1 Hydrazinopyridazine compound, process for production thereof, and use thereof as medicament TEIKOKU HORMONE MFG. CO., LTD. (JP) 1984-01-04 EP disclosed
US-4209447-A FUNGICIDES, BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1980-06-24 US disclosed
US-4165384-A ADRENERGIC BLOCKING AGENTS, CARDIOVASCULAR DISORDERS AKTIEBOLAGET HASSLE (SE) 1979-08-21 US disclosed
US-4139540-A FUNGICIDE, BACTERICIDE INTERMEDIATE JANSSEN PHARMACEUTICA N.V. (BE) 1979-02-13 US disclosed
US-3969512-A N,N'bis-(3-phenoxy-2-hydroxy-propyl)-alkylenediamines and salts thereof BOEHRINGER INGELHEIM GMBH (DT) 1976-07-13 US disclosed