SCHEMBL2337120

SCHEMBL2337120

Clc1ccc(Cl)c(OCC2CO2)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
GLA P06280 1/20 0.49
TSHR P16473 2/20 0.47
TP53 P04637 1/20 0.47
CYP3A4 P08684 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
HIF1A Q16665 1/20 0.47
CYP1A2 P05177 2/20 0.44
CYP2C19 P33261 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
DRD4 P21917 8/20 0.42
DRD2 P14416 1/20 0.42
LMNA P02545 1/20 0.42
MEN1 O00255 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29847389 0.86 ALDH1A1 (0.49) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL2338368 0.86 ALDH1A1 (0.49) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL7962015 0.86 ALDH1A1 (0.49) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL7962011 0.86 ALDH1A1 (0.49) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL13651811 0.85 ALDH1A1 (0.60) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL4177996 0.83 ALDH1A1 (0.46) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL3354399 0.83 ALDH1A1 (0.46) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL4947451 0.83 ALDH1A1 (0.54) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL30161198 0.83 TTR (0.45) ALDH1A1GLATSHRTP53CYP3A4
SCHEMBL2230996 0.83 TTR (0.45) ALDH1A1GLATSHRTP53CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110467795-B Low-viscosity liquid oxygen compatible epoxy resin system for wet-process fiber winding and preparation method thereof 大连理工大学 2021-02-23 CN claimed
CN-110467795-A A kind of low viscosity liquid oxygen compatible epoxy system and preparation method thereof for wet laid fiber winding UNIV DALIAN TECH 2019-11-19 CN claimed
CN-110467795-B Low-viscosity liquid oxygen compatible epoxy resin system for wet-process fiber winding and preparation method thereof 大连理工大学 2021-02-23 CN disclosed
CN-110467795-A A kind of low viscosity liquid oxygen compatible epoxy system and preparation method thereof for wet laid fiber winding UNIV DALIAN TECH 2019-11-19 CN disclosed
US-20190092727-A1 Piperidine Compounds, Pharmaceutical Composition Comprising The Same And Its Use SK BIOPHARMACEUTICALS CO., LTD. (KR) 2019-03-28 US disclosed
US-10144709-B2 Piperidine compounds, pharmaceutical composition comprising the same and its use SK BIOPHARMACEUTICALS CO., LTD. (KR) 2018-12-04 US disclosed
CN-105646331-B Piperidine compounds, the medical composition and its use containing the compound 爱思开生物制药株式会社 2018-07-03 CN disclosed
US-20170275250-A1 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE SK BIOPHARMACEUTICALS CO LTD (KR) 2017-09-28 US disclosed
US-9676718-B2 Piperidine compounds, pharmaceutical composition comprising the same and its use SK BIOPHARMACEUTICALS CO., LTD. (KR) 2017-06-13 US disclosed
US-9593102-B2 Piperidine compounds, pharmaceutical composition comprising the same and its use SK BIOPHARMACEUTICALS CO., LTD. (KR) 2017-03-14 US disclosed
US-20160362374-A1 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE SK BIOPHARMACEUTICALS CO LTD (KR) 2016-12-15 US disclosed
US-4604468-A ADRENERIC BLOCKING AGENTS, ANTIDEPRESSANT BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 1986-08-05 US disclosed
US-4438128-A ADRENERGIC BLOCKERS BOEHRINGER MANNHEIM GMBH (DE) 1984-03-20 US disclosed
US-4381309-A ADRENERGIC BLOCKING AGENTS; ANTIDEPRESSANTS BOEHRINGER INGELHEIM GMBH (DE) 1983-04-26 US disclosed
US-4343800-A ANTIDEPRESSANTS; ADRENERGIC BLOCKING, HYPOTENSIVE, AND ANTIARRHYTHMIA AGENTS BOEHRINGER INGELHEIM GMBH (DE) 1982-08-10 US disclosed
US-4296117-A ADRENERGIC BLOCKING AGENTS, ANTIDEPRESSANTS BOEHRINGER INGELHEIM GMBH (DE) 1981-10-20 US disclosed
US-4256756-A ADRENERGIC BLOCKING AGENTS, ANTIDEPRESSANTS BOEHRINGER INGELHEIM GMBH (DE) 1981-03-17 US disclosed
US-4255430-A ANDRENERGIC RECEPTOR BLOCKING AGENTS BOEHRINGER INGELHEIM GMBH (DE) 1981-03-10 US disclosed
US-4212877-A ANTIDEPRESSANTS, ADRENERGIC BLOCKING AGENTS BOEHRINGER INGELHEIM GMBH (DE) 1980-07-15 US disclosed
US-4110472-A CEREBROVASCULAR INSUFFICIENCY, PSYCHOSTIMULATION BAYER AKTIENGESELLSCHAFT (DE) 1978-08-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170275250-A1 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE PGC, VIP, PIGO ALDH1A1 365/4885GLA 3931/4885TSHR 3988/4885
US-10144709-B2 Piperidine compounds, pharmaceutical composition comprising the same and its use PGC, VIP, PIGO ALDH1A1 365/4885GLA 3931/4885TSHR 3988/4885
US-20190092727-A1 Piperidine Compounds, Pharmaceutical Composition Comprising The Same And Its Use PGC, VIP, PIGO ALDH1A1 365/4885GLA 3931/4885TSHR 3988/4885
US-20160362374-A1 PIPERIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME AND ITS USE PGC, VIP, PIGO ALDH1A1 365/4885GLA 3931/4885TSHR 3988/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.