Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | OXGR1 | Q96P68 | 1/20 | 0.48 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21303558 | 0.85 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1544685 | 0.83 | RXRA (0.60) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1545045 | 0.83 | ALDH1A1 (0.67) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL30566753 | 0.83 | ALDH1A1 (0.67) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL3927703 | 0.82 | HPGD (0.59) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL3821263 | 0.81 | NOTUM (0.65) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL18650263 | 0.80 | NPC1 (0.89) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL22613611 | 0.79 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1544569 | 0.79 | NOTUM (0.53) | NPC1RAB9ASMN1; SMN2TP53TSHR | |
| SCHEMBL1544574 | 0.79 | ALDH1A1 (0.49) | NPC1RAB9ASMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2008-02-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080045571-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | GRM5, GRIK5, GRM2 | NPC1 554/4885RAB9A 1926/4885SMN1; SMN2 1409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.