Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4952635 | 0.92 | TDP1 (0.50) | TDP1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4951169 | 0.82 | GRIA4 (0.51) | TDP1ALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL4950190 | 0.82 | TDP1 (0.61) | TDP1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL4953785 | 0.79 | ALOX5AP (0.55) | TDP1MAPTNPSR1TTRHPGD | |
| SCHEMBL4950432 | 0.79 | SRD5A2 (0.49) | TDP1ALDH1A1MAPTKDM4ENPSR1 | |
| SCHEMBL9474035 | 0.79 | TSHR (0.60) | ALDH1A1MAPTKDM4ENPSR1TTR | |
| SCHEMBL4950018 | 0.79 | TDP1 (0.51) | TDP1GAASMN1; SMN2POLBALOX5AP | |
| SCHEMBL4953795 | 0.79 | TDP1 (0.47) | TDP1TTRALOX5APFEN1PTPRC | |
| SCHEMBL4950547 | 0.77 | TDP1 (0.47) | TDP1TTRALOX5APFEN1PTPRC | |
| SCHEMBL6513336 | 0.74 | MCOLN3 (0.55) | TDP1ALDH1A1NPSR1L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |