Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KMO | O15229 | 1/20 | 0.50 |
| ▸ | ACLY | P53396 | 3/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.45 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | LDHB | P07195 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951169 | 0.89 | GRIA4 (0.51) | TDP1ACLYMCL1ALOX5APFEN1 | |
| SCHEMBL4950432 | 0.83 | SRD5A2 (0.49) | TDP1ACLYMCL1ALOX5APFEN1 | |
| SCHEMBL4953785 | 0.83 | ALOX5AP (0.55) | TDP1ACLYMCL1ALOX5APFEN1 | |
| SCHEMBL6513336 | 0.83 | MCOLN3 (0.55) | TDP1ACLYMCL1ALOX5APFEN1 | |
| SCHEMBL4950190 | 0.81 | TDP1 (0.61) | TDP1ACLYALOX5APFEN1LMNA | |
| SCHEMBL4950459 | 0.81 | GRIA2 (0.54) | ALOX5APFEN1SMN1; SMN2 | |
| SCHEMBL4953795 | 0.81 | TDP1 (0.47) | TDP1MCL1ALOX5APFEN1 | |
| SCHEMBL4950547 | 0.81 | TDP1 (0.47) | TDP1MCL1ALOX5APFEN1 | |
| SCHEMBL4946259 | 0.80 | ACLY (0.45) | KMOACLYPFKFB3LMNAGAA | |
| SCHEMBL4952635 | 0.79 | TDP1 (0.50) | TDP1ALOX5APFEN1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-B1 | AMPA RECEPTOR POTENTIATORS | LILLY CO ELI (US) | 2008-11-12 | — | — | EP | disclosed |