SCHEMBL4949236

SCHEMBL4949236

COc1ccc(S(=O)(=O)c2cc(C)cc3c(Nc4cccc(F)c4)c(C(N)=O)cnc23)cc1

nearest known ligand 0.66

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 16/20 0.66
CSF1R P07333 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4944841 0.92 PDE4B (0.77) PDE4BCSF1R
SCHEMBL4946407 0.90 PDE4B (0.66) PDE4BCSF1R
SCHEMBL4952552 0.89 PDE4B (0.65) PDE4BCSF1R
SCHEMBL4948739 0.89 PDE4B (0.71) PDE4BCSF1R
SCHEMBL4949534 0.88 PDE4B (0.63) PDE4BCSF1R
SCHEMBL2479157 0.87 PDE4B (0.85) PDE4BCSF1R
SCHEMBL4946547 0.87 PDE4B (0.77) PDE4B
SCHEMBL4952294 0.85 PDE4B (0.66) PDE4BCSF1R
SCHEMBL4949063 0.85 CSF1R (0.56) PDE4BCSF1R
SCHEMBL4952401 0.83 PDE4B (0.75) PDE4BCSF1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633748-B1 QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS GLAXO GROUP LTD (GB) 2008-03-05 EP claimed