Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ACLY | P53396 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.37 |
| ▸ | CPT2 | P23786 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.33 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15243288 | 1.00 | HMGCR (0.42) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| SCHEMBL11509869 | 0.83 | HMGCR (0.52) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| SCHEMBL15256888 | 0.80 | HMGCR (0.31) | HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL27477794 | 0.76 | HMGCR (0.46) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| SCHEMBL10338280 | 0.74 | HMGCR (0.50) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| SCHEMBL9245370 | 0.74 | ACLY (0.46) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| SCHEMBL17146083 | 0.72 | TDP1 (0.35) | HMGCRCHRM1TBXA2RADRA1ATDP1 | |
| Mevalonic Acid SCHEMBL120276 | 0.71 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| Mevalonic Acid SCHEMBL120275 | 0.71 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1AACLY | |
| Mevalonic Acid SCHEMBL8854071 | 0.71 | HMGCR (0.67) | HMGCRCHRM1TBXA2RADRA1AACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8710032-B2 | Inhibitors of the mevalonate pathway of Streptococcus pneumoniae | NORTHWESTERN UNIVERSITY (US) | 2014-04-29 | — | — | US | disclosed |
| WO-2008108834-A2 | INHIBITORS OF THE MEVALONATE PATHWAY OF STREPTOCOCCUS PNEUMONIAE | NORTHWESTERN UNIVERSITY (US) | 2008-09-12 | — | — | WO | disclosed |