Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4943343 | 0.86 | TTR (0.53) | TTRFTOLMNAMAPTTDP1 | |
| SCHEMBL7371244 | 0.73 | TTR (0.71) | TTRLMNAMAPTSMN1; SMN2POLB | |
| SCHEMBL7367724 | 0.70 | TTR (0.57) | TTRLMNAMAPTJUNTDP1 | |
| SCHEMBL3584563 | 0.69 | TTR (0.53) | TTRFTOLMNAMAPTPOLB | |
| SCHEMBL7369924 | 0.69 | TTR (0.64) | TTRFTOLMNAMAPTSMN1; SMN2 | |
| SCHEMBL7365333 | 0.69 | TTR (0.75) | TTRLMNAMAPTSMN1; SMN2EGFR | |
| SCHEMBL3583434 | 0.69 | CA12 (0.66) | TTRFTOMAPTSMN1; SMN2EGFR | |
| SCHEMBL5598228 | 0.69 | LMNA (0.66) | TTRFTOLMNAMAPTSMN1; SMN2 | |
| SCHEMBL31059024 | 0.69 | LMNA (0.66) | TTRFTOLMNAMAPTSMN1; SMN2 | |
| SCHEMBL31059025 | 0.69 | LMNA (0.66) | TTRFTOLMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907382-A1 | NITROCATECHOL DERIVATIVES AS COMT INHIBITORS | Portela & C.A. S.A (PT) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007013830-A1 | NITROCATECHOL DERIVATIVES AS COMT INHIBITORS | PORTELA & CA. S.A. (PT) | 2007-02-01 | — | — | WO | disclosed |