Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.41 |
| ▸ | CASP7 | P55210 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4949375 | 0.81 | MAPK14 (0.78) | MAPK14DDR2 | |
| SCHEMBL593301 | 0.76 | DDR2 (0.67) | MEN1KMT2AMAPK14BRAFDDR2 | |
| SCHEMBL6400541 | 0.74 | PLAU (0.59) | MEN1KMT2AMAPK14GPR183PLAU | |
| SCHEMBL16106995 | 0.73 | GPR183 (0.59) | MEN1KMT2AMAPK14GPR183PLAU | |
| SCHEMBL4948810 | 0.70 | MAPK14 (0.75) | MAPK14DDR2 | |
| SCHEMBL4949200 | 0.68 | MAPK14 (1.00) | MAPK14DDR2 | |
| SCHEMBL6883068 | 0.66 | SMN1; SMN2 (0.54) | MEN1KMT2AGPR183PLAUBRAF | |
| SCHEMBL13043185 | 0.65 | RAB9A (0.55) | MEN1KMT2ACASP3CASP7ALDH1A1 | |
| SCHEMBL15007943 | 0.64 | GPR183 (0.54) | MEN1KMT2AMAPK14GPR183PLAU | |
| SCHEMBL14155407 | 0.64 | MAPK14 (0.42) | MEN1KMT2AMAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008089034-A2 | CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2008-07-24 | — | — | WO | disclosed |