SCHEMBL4949059

SCHEMBL4949059

Fc1c2ccccc2c(F)c2ccccc12

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.41
HSD17B10 Q99714 4/20 0.41
CYP2A6 P11509 3/20 0.41
TSHR P16473 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
CYP1A2 P05177 3/20 0.39
IDO1 P14902 1/20 0.39
GPR3 P46089 4/20 0.37
HPRT1 P00492 2/20 0.37
KDM4E B2RXH2 2/20 0.35
ACHE P22303 1/20 0.35
MAPK1 P28482 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
ALOX12 P18054 1/20 0.33
NFE2L2 Q16236 1/20 0.33
HIF1A Q16665 1/20 0.33
CYP1B1 Q16678 1/20 0.33
THRB P10828 1/20 0.33
HPGD P15428 1/20 0.33
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3465621 0.89 IDO1 (0.40) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL2887670 0.88 ALDH1A1 (0.39) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL6309502 0.88 HPRT1 (0.42) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL30366320 0.88 ALDH1A1 (0.39) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL23502291 0.84 POLB (0.36) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL15352181 0.84 CYP2A6 (0.32) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL15352188 0.84 KEAP1 (0.33) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL14596476 0.84 TSHR (0.44) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL4829479 0.82 ALDH1A1 (0.35) ALDH1A1HSD17B10CYP2A6TSHRTDP1
SCHEMBL22953480 0.80 HPRT1 (0.41) ALDH1A1HSD17B10TSHRTDP1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1072668-B1 Organic electroluminescent device SONY CORP (JP) 2008-07-30 EP disclosed
EP-1122746-B1 Composition for film formation and insulating film JSR CORP (JP) 2004-09-22 EP disclosed
US-6495274-B1 DI-P-AMINOSTYRYL ANTHRACENE SUBSTITUTED WITH CYANO, NITRO OR HALOGEN GROUPS SONY CORPORATION (JP) 2002-12-17 US disclosed
US-6468589-B2 A HEAT-CURED POLYETHER BASED ON A 9,9-BIS(P-HYDROXYPHENYL)-FLUORENE HAVING AT LEAST ONE ALKYL SUBSTITUENT AND A DIHYDROXY AROMATIC COMONOMER; LOW DIELECTRIC PROTECTIVE COATINGS; HEAT RESISTANCE; NONCRACKING JSR CORPORATION (JP) 2002-10-22 US disclosed
US-20010012870-A1 Composition for film formation and insulating film JSR CORPORATION (JP) 2001-08-09 US disclosed
EP-1122746-A1 Composition for film formation and insulating film JSR Corporation (JP) 2001-08-08 EP disclosed
EP-1072668-A2 Organic electroluminescent device SONY CORPORATION (JP) 2001-01-31 EP disclosed
US-6034206-A POLYANILINES; HEAT, CHEMICAL AND SOLVENT RESISTANCE TOSOH CORPORATION (JP) 2000-03-07 US disclosed
EP-0626942-B1 BICYCLO[2.2.2.]OCTANE DERIVATIVES AS CHOLESTOCYSTOKININ INHIBITORS BLACK JAMES FOUNDATION (GB) 1997-04-23 EP disclosed
US-5514683-A LIGANDS FKOR CHOLECYSTOKININ OR GASTRIN RECEPTORS JAMES BLACK FOUNDATION LIMITED (GB) 1996-05-07 US disclosed
EP-0626942-A1 BICYCLO 2.2.2.]OCTANE DERIVATIVES AS CHOLESTOCYSTOKININ INHIBITORS. BLACK JAMES FOUNDATION (GB) 1994-12-07 EP disclosed
WO-1993016982-A1 BICYCLO[2.2.2.]OCTANE DERIVATIVES AS CHOLESTOCYSTOKININ INHIBITORS JAMES BLACK FOUNDATION LIMITED (GB) 1993-09-02 WO disclosed