Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL5057645 | 0.90 | TSHR (0.50) | TSHR | |
| Dimethyl Sulfoxide SCHEMBL1608850 | 0.87 | ALDH1A1 (0.37) | TSHR | |
| Dimethyl Sulfoxide SCHEMBL4981240 | 0.87 | ALDH1A1 (0.37) | TSHR | |
| Dimethylformamide SCHEMBL57861 | 0.87 | TSHR (0.60) | TSHR | |
| Dimethyl Sulfoxide SCHEMBL7524099 | 0.84 | ALDH1A1 (0.35) | TSHR | |
| Dimethylformamide SCHEMBL11211737 | 0.84 | TSHR (0.56) | TSHR | |
| Dimethylformamide SCHEMBL23532600 | 0.84 | TSHR (0.64) | TSHR | |
| Dimethylformamide SCHEMBL746068 | 0.84 | TSHR (0.64) | TSHR | |
| Dimethylformamide SCHEMBL5360 | 0.84 | — | — | |
| Dimethylformamide SCHEMBL28144582 | 0.81 | TSHR (0.60) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968943-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | MSN Laboratories Limited (IN) | 2008-09-17 | — | — | EP | claimed |
| WO-2007069261-A1 | AN IMPROVED PROCESS FOR THE PREPARATION OF MONTELUKAST AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS | MSN LABORATORIES LIMITED (IN) | 2007-06-21 | — | — | WO | claimed |
| EP-1077686-A1 | EXTERNALLY TRIGGERED MICROCAPSULES | NASA/Johnson Space Center (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059556-A1 | EXTERNALLY TRIGGERED MICROCAPSULES | NASA/JOHNSON SPACE CENTER (US) | 1999-11-25 | — | — | WO | disclosed |
| CN-1020906-C | PROCESS FOR PREPARATION OF 2-(HETEROCYCLYLALKYL) IMIDAZOPYRIDINES COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 1993-05-26 | — | — | CN | disclosed |
| CN-1030587-A | 2-(Heterocyclylalkyl) imidazopyridine | JANSSEN PHARMACEUTICA NV (BE) | 1989-01-25 | — | — | CN | disclosed |