Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dimethyl Sulfoxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | APEX1 | P27695 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethyl Sulfoxide SCHEMBL1608850 | 0.97 | ALDH1A1 (0.37) | ALDH1A1TSHRCA1NFKB1THPO | |
| Dimethyl Sulfoxide SCHEMBL4981240 | 0.97 | ALDH1A1 (0.37) | ALDH1A1TSHRCA1NFKB1THPO | |
| Dimethylformamide SCHEMBL4949249 | 0.84 | TSHR (0.45) | TSHR | |
| Water SCHEMBL461938 | 0.83 | — | — | |
| Dimethyl Sulfoxide SCHEMBL9878876 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL7078366 | 0.79 | — | — | |
| Methyl Alcohol SCHEMBL28488777 | 0.79 | — | — | |
| Water SCHEMBL10659521 | 0.79 | TSHR (0.44) | ALDH1A1TSHRCA1NFKB1THPO | |
| SCHEMBL1925147 | 0.79 | ALDH1A1 (0.50) | ALDH1A1TSHRCA1NFKB1THPO | |
| SCHEMBL4820393 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0546057-B1 | GAS SEPARATION MEMBRANE WITH ULTRATHIN LAYER | AIR LIQUIDE (FR) | 2002-01-30 | — | — | EP | disclosed |
| EP-0422884-B1 | Surfactant treatment of aromatic polyimide gas separation membranes | DU PONT (US) | 1997-03-12 | — | — | EP | disclosed |
| US-5160353-A | Multilayer | E. I. DU PONT DE NEMOURS & COMPANY (US) | 1992-11-03 | — | — | US | disclosed |
| US-5034024-A | Improvement in permselectivity of aromatic polyimide membranes | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-07-23 | — | — | US | disclosed |
| EP-0422884-A1 | Surfactant treatment of aromatic polyimide gas separation membranes | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-04-17 | — | — | EP | disclosed |