Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.60 |
| ▸ | CSF1R | P07333 | 5/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4951405 | 0.87 | PDE4B (0.63) | PDE4BCSF1RLRRK2KCNH2ATM | |
| SCHEMBL4948930 | 0.86 | CSF1R (0.53) | PDE4BCSF1RLRRK2 | |
| SCHEMBL2483485 | 0.84 | PDE4B (0.69) | PDE4BCSF1RLRRK2KCNH2ATM | |
| SCHEMBL4952317 | 0.84 | PDE4B (0.68) | PDE4BCSF1R | |
| SCHEMBL2480839 | 0.80 | PDE4B (0.72) | PDE4BCSF1RLRRK2KCNH2ATM | |
| SCHEMBL4949687 | 0.79 | PDE4B (0.44) | PDE4BCSF1RLRRK2 | |
| SCHEMBL4948827 | 0.79 | PDE4B (0.71) | PDE4BCSF1R | |
| SCHEMBL27649772 | 0.79 | PDE4B (0.51) | PDE4BCSF1RKCNH2ATM | |
| SCHEMBL4952735 | 0.78 | PDE4B (0.56) | PDE4BCSF1RLRRK2KCNH2ATM | |
| SCHEMBL4949887 | 0.77 | PDE4B (0.55) | PDE4BCSF1RLRRK2KCNH2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |