Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950077 | 0.90 | PDE4B (0.40) | THRBCSF1RPDE4BMAPTGAA | |
| SCHEMBL4949579 | 0.89 | THRB (0.38) | THRBCSF1RPDE4BMAPTGAA | |
| SCHEMBL1275624 | 0.86 | PDE4B (0.46) | THRBCSF1RPDE4BMAPTGAA | |
| SCHEMBL2479664 | 0.79 | PDE4B (0.56) | THRBCSF1RPDE4BKCNH2ATM | |
| SCHEMBL2480491 | 0.79 | PDE4B (0.46) | THRBCSF1RPDE4BMAPTGAA | |
| SCHEMBL4949887 | 0.78 | PDE4B (0.55) | THRBCSF1RPDE4BKCNH2ATM | |
| SCHEMBL27670156 | 0.75 | KCNH2 (0.40) | THRBCSF1RPDE4BMAPTGAA | |
| SCHEMBL4949692 | 0.75 | PDE4B (0.42) | CSF1RPDE4B | |
| SCHEMBL5929641 | 0.71 | CSF1R (0.61) | CSF1R | |
| SCHEMBL1276080 | 0.70 | PDE4B (0.78) | CSF1RPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633748-B1 | QUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-03-05 | — | — | EP | claimed |