Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 12/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 12/20 | 0.52 |
| ▸ | GABRA5 | P31644 | 12/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.49 |
| ▸ | GABRA6 | Q16445 | 5/20 | 0.49 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571594 | 0.88 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3872242 | 0.87 | GABRG2 (0.60) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL5188935 | 0.86 | GABRG2 (0.51) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2823551 | 0.82 | GABRG2 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL2824528 | 0.80 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3571855 | 0.80 | GABRG2 (0.66) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3871120 | 0.79 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3574483 | 0.77 | GABRG2 (0.65) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL3872594 | 0.76 | SMN1; SMN2 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL6809989 | 0.75 | OPRK1 (0.57) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809297-B1 | IMIDAZO[1,5A]TRIAZOLO[1,5D]BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | EP | disclosed |