Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29546918 | 0.80 | ATR (0.42) | — | |
| SCHEMBL19494290 | 0.78 | ERN1 (0.33) | ALDH1A1ERN1 | |
| SCHEMBL3347731 | 0.74 | DAO (0.53) | HSD17B10GAAPKMALOX15ALDH1A1 | |
| SCHEMBL12299530 | 0.72 | HSD17B10 (0.39) | DYRK1AFSCN1HSD17B10GAAPKM | |
| SCHEMBL16246345 | 0.72 | MEN1 (0.59) | HSD17B10ALOX15ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11578885 | 0.71 | ALDH1A1 (0.44) | HSD17B10GAAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7976116 | 0.70 | CA2 (0.44) | ALDH1A1MAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL19260372 | 0.69 | ALDH1A1 (0.53) | GAAALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL23450058 | 0.68 | ALDH1A1 (0.62) | HSD17B10GAAPKMALOX15ALDH1A1 | |
| SCHEMBL19260400 | 0.68 | ALDH1A1 (0.46) | HSD17B10PKMALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411074-B2 | Process and intermediates for the preparation of the thienopyrrole derivatives | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| US-7411074-B2 | Process and intermediates for the preparation of the thienopyrrole derivatives | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| US-7411074-B2 | Process and intermediates for the preparation of the thienopyrrole derivatives | ASTRAZENECA AB (SE) | 2008-08-12 | — | — | US | disclosed |
| US-20060035953-A1 | Cyclizing an N-carboxymethyl-N-alkanoyl-3-formyl-2-thiophenylamine and optionally amidating the product | ASTRAZENECA AB (SE) | 2006-02-16 | — | — | US | disclosed |
| EP-1549654-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF THIENOPYRROLE DERIVATIVES | Astrazeneca AB (SE) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031194-A1 | PROCESS AND INTERMEDIATES FOR THE PREPARATION OF THE THIENOPYRROLE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035953-A1 | Cyclizing an N-carboxymethyl-N-alkanoyl-3-formyl-2-thiophenylamine and optionally amidating the product | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NAT1, ADCY7 | DYRK1A 4574/4885FSCN1 1328/4885HSD17B10 1012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.