⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL371069 | 0.79 | TSHR (0.54) | — | |
| SCHEMBL5320628 | 0.79 | TSHR (0.54) | — | |
| SCHEMBL21114388 | 0.77 | TSHR (0.57) | — | |
| SCHEMBL302811 | 0.77 | — | — | |
| SCHEMBL10141202 | 0.77 | — | — | |
| SCHEMBL10141203 | 0.77 | — | — | |
| SCHEMBL28298 | 0.77 | — | — | |
| 2-Acetylpyrrole SCHEMBL150349 | 0.75 | — | — | |
| SCHEMBL15338778 | 0.75 | — | — | |
| SCHEMBL4325727 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034596-A2 | PYRROLECARBONYLIMINO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-05-17 | — | — | WO | claimed |
| EP-0975341-A1 | SYNERGISTIC ANTITUMOR COMPOSITION CONTAINING A NAPHTHALENSULPHONIC ACID DERIVATIVE | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-02-02 | — | — | EP | claimed |
| WO-1999034796-A1 | SYNERGISTIC ANTITUMOR COMPOSITION CONTAINING A NAPHTHALENSULPHONIC ACID DERIVATIVE | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-07-15 | — | — | WO | claimed |
| WO-1991010649-A1 | NEW UREIDO DERIVATIVES OF POLY-4-AMINO-2-CARBOXY-1-METHYL COMPOUNDS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1991-07-25 | — | — | WO | claimed |
| US-11912699-B2 | Tau-protein targeting compounds and associated | ARVINAS OPERATIONS, INC. (US) | 2024-02-27 | — | — | US | disclosed |
| WO-2019148412-A1 | ANTI-PD-1/LAG3 BISPECIFIC ANTIBODIES | MERCK SHARP & DOHME CORP. (US) | 2019-08-08 | — | — | WO | disclosed |
| WO-2019148410-A1 | ANTI-PD-1 ANTIBODIES | MERCK SHARP & DOHME CORP. (US) | 2019-08-08 | — | — | WO | disclosed |
| WO-2016095088-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2016095089-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-06-23 | — | — | WO | disclosed |
| WO-2015051766-A1 | AMIDS SUBSTITUTED INDAZOLE DERIVATIVEES AS PLOY (ADP-RIBOSE) POLYMERASE INHIBITORS | BETTA PHARMACEUTICALS CO., LTD (CN) | 2015-04-16 | — | — | WO | disclosed |
| US-7368576-B2 | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents | PROBIODRUG AG (DE) | 2008-05-06 | — | — | US | disclosed |
| US-20060293248-A1 | Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents | PROBIODRUG AG | 2006-12-28 | — | — | US | disclosed |
| WO-2001034596-A3 | PYRROLECARBONYLIMINO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARM INC (US) | 2002-03-07 | — | — | WO | disclosed |
| US-6348464-B1 | Pyrrolecarbonylimino derivatives as naaladase inhibitors | GUILFORD PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6348464-B1 | Pyrrolecarbonylimino derivatives as naaladase inhibitors | GUILFORD PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| US-6348464-B1 | Pyrrolecarbonylimino derivatives as naaladase inhibitors | GUILFORD PHARMACEUTICALS, INC. | 2002-02-19 | — | — | US | disclosed |
| WO-2001034596-A2 | PYRROLECARBONYLIMINO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| WO-2001034596-A2 | PYRROLECARBONYLIMINO DERIVATIVES AS NAALADASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2001-05-17 | — | — | WO | disclosed |
| EP-0975341-A1 | SYNERGISTIC ANTITUMOR COMPOSITION CONTAINING A NAPHTHALENSULPHONIC ACID DERIVATIVE | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-02-02 | — | — | EP | disclosed |
| WO-1999034796-A1 | SYNERGISTIC ANTITUMOR COMPOSITION CONTAINING A NAPHTHALENSULPHONIC ACID DERIVATIVE | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-07-15 | — | — | WO | disclosed |