Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 7/20 | 0.37 |
| ▸ | MAOA | P21397 | 3/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18650069 | 0.77 | TSHR (0.43) | IDO1TAAR1KDM4EALDH1A1MAPT | |
| SCHEMBL5953661 | 0.77 | IDO1 (0.47) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL5439593 | 0.74 | IDO1 (0.52) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL11957478 | 0.74 | IDO1 (0.52) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL7200840 | 0.70 | MAOB (0.37) | IDO1APPMAOBMAOATAAR1 | |
| SCHEMBL28066876 | 0.70 | IDO1 (0.52) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL30338358 | 0.70 | IDO1 (0.52) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL9366824 | 0.67 | IDO1 (0.48) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL1995347 | 0.66 | IDO1 (0.58) | IDO1APPMAOBTAAR1RXRA | |
| SCHEMBL4686836 | 0.66 | IDO1 (0.52) | IDO1APPMAOBMAOATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7425537-B2 | SH2 domain binding inhibitors | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-09-16 | — | — | US | disclosed |
| US-20060167222-A1 | Sh2 domain binding inhibitors | GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2006-07-27 | — | — | US | disclosed |
| US-6977241-B2 | SH2 domain binding inhibitors | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2005-12-20 | — | — | US | disclosed |
| US-20040048788-A1 | Sh2 domain binding inhibitors | DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, OF THE | 2004-03-11 | — | — | US | disclosed |
| EP-1383792-A2 | SH2 DOMAIN BINDING INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2004-01-28 | — | — | EP | disclosed |
| WO-2004003005-A2 | SH2 DOMAIN BINDING INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2004-01-08 | — | — | WO | disclosed |
| WO-2002016407-A2 | SH2 DOMAIN BINDING INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-02-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048788-A1 | Sh2 domain binding inhibitors | ACP1, PHLPP1, SORBS1 | IDO1 854/4885APP 3817/4885MAOB 3764/4885 |
| US-20060167222-A1 | Sh2 domain binding inhibitors | ACP1, HCLS1, LASP1 | IDO1 1630/4885APP 4345/4885MAOB 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.