Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | SCN1A | P35498 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955705 | 0.80 | HRH3 (0.41) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL27814848 | 0.78 | HRH3 (0.39) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL5146583 | 0.77 | TDP1 (0.35) | HRH3ALDH1A1LMNAKDM4E | |
| SCHEMBL7551660 | 0.76 | HRH3 (0.42) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL23979805 | 0.73 | KEAP1 (0.48) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL5127782 | 0.73 | HRH3 (0.39) | HRH3ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7161466 | 0.70 | HRH3 (0.41) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL21093848 | 0.70 | HRH3 (0.49) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL9917383 | 0.70 | HRH3 (0.51) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 | |
| SCHEMBL2573854 | 0.69 | TDP1 (0.36) | HRH3MAPK1ALDH1A1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7358222-B2 | Preventing airway mucus production by administration of EGF-R antagonists | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-04-15 | — | — | US | claimed |