Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4955705 | 0.82 | HRH3 (0.41) | HRH3KDM4ECYP2D6ALDH1A1 | |
| SCHEMBL4686233 | 0.81 | CYP3A4 (0.34) | HRH3CYP2D6 | |
| SCHEMBL1718577 | 0.80 | CYP3A4 (0.36) | HRH3CYP2D6MEN1KMT2A | |
| SCHEMBL4955698 | 0.73 | HRH3 (0.41) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5492084 | 0.72 | CNR2 (0.35) | HRH3KDM4ECYP2D6ALDH1A1SMN1; SMN2 | |
| SCHEMBL18024004 | 0.71 | HRH3 (0.50) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9129 | 0.70 | — | — | |
| SCHEMBL18024010 | 0.70 | HRH3 (0.53) | HRH3SMN1; SMN2 | |
| SCHEMBL3958321 | 0.68 | L3MBTL1 (0.43) | HRH3ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL10957514 | 0.68 | HRH3 (0.65) | HRH3KDM4ECYP2D6ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994024-A2 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | claimed |
| WO-2007099323-A2 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | claimed |