SCHEMBL4956626

SCHEMBL4956626

C=CCC(C)(N)Cc1cccnc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.43
CYP1A2 P05177 3/20 0.43
CYP2C9 P11712 2/20 0.43
CYP2D6 P10635 2/20 0.43
CYP2C19 P33261 1/20 0.43
HIF1A Q16665 1/20 0.43
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
SLC6A3 Q01959 1/20 0.43
KCNH2 Q12809 1/20 0.43
CHRNA7 P36544 1/20 0.42
FDPS P14324 4/20 0.42
BTN3A1 O00481 1/20 0.42
PDE3A Q14432 1/20 0.42
CHRNB2 P17787 3/20 0.41
CHRNA4 P43681 3/20 0.41
CYP2A6 P11509 1/20 0.40
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15941315 0.78 SLC6A2 (0.57) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL8366344 0.78 CHRNA7 (0.52) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL2376699 0.74 CYP1A2 (0.51) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
Bicarbonate SCHEMBL1730381 0.74 ALDH1A1 (0.50) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL2996471 0.74 CYP19A1 (0.44) CYP3A4CYP1A2CYP2C9CYP2C19HIF1A
SCHEMBL74145 0.74 CYP1A2 (0.55) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL31358573 0.74 CYP1A2 (0.55) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
Ammonia Solution, Strong SCHEMBL27962089 0.72 CHRNB2 (0.57) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL30082314 0.71 CYP3A4 (0.55) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19
SCHEMBL27962088 0.71 CYP3A4 (0.55) CYP3A4CYP1A2CYP2C9CYP2D6CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1997806-A1 Pahrmaceutical compositions for prevention and treatment of central nervous system disorders Targacept, Inc. (US) 2008-12-03 EP disclosed
EP-0900200-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R.J. REYNOLDS TOBACCO COMPANY (US) 1999-03-10 EP disclosed
WO-1997040011-A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTION AND TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS R. J. REYNOLDS TOBACCO COMPANY (US) 1997-10-30 WO disclosed