⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5023452 | 0.86 | TSHR (0.61) | — | |
| SCHEMBL2217142 | 0.85 | TSHR (0.57) | — | |
| SCHEMBL18116498 | 0.83 | — | — | |
| SCHEMBL205336 | 0.83 | — | — | |
| SCHEMBL24804137 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL247260 | 0.81 | GABRP (0.54) | — | |
| Hydrochloric Acid SCHEMBL30244719 | 0.81 | GABRP (0.54) | — | |
| SCHEMBL28622251 | 0.81 | — | — | |
| SCHEMBL6753794 | 0.79 | SLC1A1 (0.55) | — | |
| SCHEMBL131050 | 0.79 | SLC1A1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7316999-B2 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2008-01-08 | — | — | US | disclosed |
| EP-1290024-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2003-03-12 | — | — | EP | disclosed |
| US-20020028767-A1 | Glucose dependent release of insulin from glucose sensing insulin derivatives | NOVO NORDISK A/S (DK) | 2002-03-07 | — | — | US | disclosed |
| WO-2001092334-A1 | GLUCOSE DEPENDENT RELEASE OF INSULIN FROM GLUCOSE SENSING INSULIN DERIVATIVES | NOVO NORDISK A/S (DK) | 2001-12-06 | — | — | WO | disclosed |