Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.39 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3661193 | 0.97 | KDM4E (0.61) | KDM4EGAAALDH1A1POLBEIF4A3 | |
| SCHEMBL31273523 | 0.85 | EIF4A3 (0.66) | KDM4EGAAALDH1A1POLBEIF4A3 | |
| SCHEMBL30547869 | 0.77 | EIF4A3 (0.77) | KDM4EGAAALDH1A1EIF4A3HSD17B10 | |
| SCHEMBL3643479 | 0.77 | EIF4A3 (0.77) | KDM4EGAAALDH1A1EIF4A3HSD17B10 | |
| SCHEMBL10969986 | 0.77 | KDM4E (0.66) | KDM4EGAAALDH1A1POLBHSD17B10 | |
| SCHEMBL31222329 | 0.77 | ALDH1A1 (0.74) | KDM4EGAAALDH1A1POLBHSD17B10 | |
| SCHEMBL29415468 | 0.75 | KDM4E (0.63) | KDM4EGAAALDH1A1POLBHSD17B10 | |
| SCHEMBL22184893 | 0.75 | IDH1 (0.42) | KDM4EALDH1A1EIF4A3HSD17B10HPGD | |
| SCHEMBL2806050 | 0.75 | KDM4E (0.63) | KDM4EGAAALDH1A1POLBHSD17B10 | |
| SCHEMBL2310250 | 0.74 | F7 (0.63) | KDM4EGAAALDH1A1POLBGPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871772-A1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | Theravance, Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006094063-A1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE, INC. (US) | 2006-09-08 | — | — | WO | disclosed |