Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.33 |
| ▸ | MARK3 | P27448 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958622 | 0.89 | PSEN1 (0.37) | SMN1; SMN2MEN1KMT2AROCK2PSEN1 | |
| SCHEMBL4958173 | 0.85 | PNMT (0.38) | TSHRSMN1; SMN2TACR1PNMTMAPK1 | |
| SCHEMBL17045288 | 0.76 | TSHR (0.51) | TSHRSMN1; SMN2TACR1PNMTMAPK1 | |
| SCHEMBL17045290 | 0.76 | TSHR (0.51) | TSHRSMN1; SMN2TACR1PNMTMAPK1 | |
| SCHEMBL17045289 | 0.76 | TSHR (0.51) | TSHRSMN1; SMN2TACR1PNMTMAPK1 | |
| SCHEMBL4959455 | 0.73 | CYP1A2 (0.42) | SMN1; SMN2ROCK2RAB9ANPSR1 | |
| SCHEMBL134466 | 0.71 | TSHR (0.57) | TSHRSMN1; SMN2TACR1MAPK1MEN1 | |
| SCHEMBL4960151 | 0.70 | PNMT (0.40) | SMN1; SMN2PNMTKMT2ANPSR1 | |
| SCHEMBL10732984 | 0.70 | TSHR (0.55) | TSHRSMN1; SMN2TACR1MAPK1MEN1 | |
| SCHEMBL4959312 | 0.70 | SLC6A2 (0.43) | TSHRSMN1; SMN2TACR1PNMTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879873-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006112685-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |