Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957415 | 0.89 | TSHR (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4959455 | 0.84 | CYP1A2 (0.42) | SMN1; SMN2PPARGPPARACYP1A2CYP2D6 | |
| SCHEMBL17250967 | 0.76 | GABBR2 (0.43) | PPARGPPARACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11293974 | 0.75 | SLC6A4 (0.37) | PPARGPPARACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL17045272 | 0.73 | SLC6A4 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17045271 | 0.73 | SLC6A4 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17045269 | 0.73 | SLC6A4 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4958173 | 0.73 | PNMT (0.38) | SMN1; SMN2CYP1A2CYP2D6MEN1KMT2A | |
| SCHEMBL4960151 | 0.72 | PNMT (0.40) | SMN1; SMN2CYP1A2CYP2D6KMT2A | |
| SCHEMBL19354511 | 0.71 | SLC6A4 (0.41) | SMN1; SMN2PPARGPPARACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879873-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006112685-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |