Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | EED | O75530 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2145110 | 0.88 | TSHR (0.52) | TSHRGAAPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL1753177 | 0.86 | MAPK1 (0.55) | TSHRGAAPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL2145170 | 0.85 | CYP19A1 (0.53) | TSHRGAAPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL10566878 | 0.84 | ALDH1A1 (0.52) | GAASMN1; SMN2RECQLMAPK10ALDH1A1 | |
| SCHEMBL4958156 | 0.84 | PKM (0.69) | TSHRGAAPKMSMN1; SMN2LMNA | |
| SCHEMBL11213556 | 0.81 | SMN1; SMN2 (0.55) | TSHRGAAPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL4505446 | 0.80 | NPC1 (0.51) | TSHRGAASMN1; SMN2RECQLMAPK10 | |
| SCHEMBL10567125 | 0.80 | ALDH1A1 (0.51) | TSHRSMN1; SMN2ALDH1A1LMNAEED | |
| SCHEMBL17456271 | 0.78 | SMN1; SMN2 (0.53) | TSHRGAAPKMCYP19A1SMN1; SMN2 | |
| SCHEMBL1753091 | 0.78 | SMN1; SMN2 (0.53) | TSHRGAAPKMCYP19A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937184-B2 | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators | ABBVIE B.V. (NL) | 2015-01-20 | — | — | US | disclosed |
| EP-1874734-A1 | 1H-IMIDIAZOLE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS | Solvay Pharmaceuticals B.V. (NL) | 2008-01-09 | — | — | EP | disclosed |
| US-20060194779-A1 | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators | ABBVIE B.V. (NL) | 2006-08-31 | — | — | US | disclosed |
| WO-2006087355-A1 | 1H-IMIDIAZOLE DERIVATIVES AS CANNABINOID CB2 RECEPTOR MODULATORS | SOLVAY PHARMACEUTICALS B.V. (NL) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194779-A1 | 1H-imidazole derivatives as cannabinoid CB2 receptor modulators | CNR1, CNR2, HRH4 | TSHR 590/4885GAA 4298/4885PKM 2851/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.