Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4108130 | 0.89 | PGR (0.64) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL4959617 | 0.88 | PGR (0.50) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL4962255 | 0.85 | MRGPRX4 (0.40) | PGR | |
| SCHEMBL4100044 | 0.84 | PGR (0.36) | PGRKDM4EPOLBMAPT | |
| SCHEMBL4959744 | 0.83 | PGR (0.47) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL4104942 | 0.80 | PGR (0.47) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL13889242 | 0.79 | PGR (0.48) | PGRCYP11B1CYP11B2KDM4EPOLB | |
| SCHEMBL4103189 | 0.78 | PGR (0.49) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL4102713 | 0.78 | PGR (0.64) | PGRCYP11B1CYP11B2KDM4ESCN9A | |
| SCHEMBL4104316 | 0.77 | PGR (0.42) | PGRFPR2PROKR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874732-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111856-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2006-10-26 | — | — | WO | disclosed |