Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.39 |
| ▸ | PGR | P06401 | 3/20 | 0.38 |
| ▸ | AR | P10275 | 5/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4959655 | 0.91 | MRGPRX4 (0.39) | MRGPRX4FFAR4PGRARNR3C2 | |
| SCHEMBL4098285 | 0.89 | PGR (0.48) | MRGPRX4FFAR4PGRARNR3C2 | |
| SCHEMBL4100044 | 0.87 | PGR (0.36) | FFAR4PGRMCL1 | |
| SCHEMBL4958159 | 0.85 | PGR (0.52) | PGR | |
| SCHEMBL4976120 | 0.84 | PGR (0.46) | MRGPRX4FFAR4PGRAR | |
| SCHEMBL4098007 | 0.82 | MRGPRX4 (0.37) | MRGPRX4FFAR4PGRARNR3C2 | |
| SCHEMBL4112533 | 0.81 | PGR (0.48) | MRGPRX4FFAR4PGRARNR3C2 | |
| SCHEMBL4959670 | 0.79 | MRGPRX4 (0.39) | MRGPRX4PGRAR | |
| SCHEMBL4104136 | 0.78 | LMNA (0.36) | PGRKDM1A | |
| SCHEMBL4960690 | 0.78 | PGR (0.35) | FFAR4PGRMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874732-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111856-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2006-10-26 | — | — | WO | disclosed |