Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.60 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | SPR | P35270 | 1/20 | 0.51 |
| ▸ | CCR1 | P32246 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CCNC | P24863 | 1/20 | 0.50 |
| ▸ | CDK8 | P49336 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098866 | 0.90 | HSD11B1 (0.58) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL25175392 | 0.87 | HSD11B1 (0.53) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL23453444 | 0.86 | SMN1; SMN2 (0.49) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL12497298 | 0.85 | NPC1 (0.57) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3183837 | 0.84 | RAB9A (0.67) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3184817 | 0.84 | RAB9A (0.67) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL3183827 | 0.84 | RAB9A (0.67) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL15577442 | 0.83 | RAB9A (0.50) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL25322608 | 0.83 | MAPT (0.58) | NPC1TP53RAB9ASMN1; SMN2LMNA | |
| SCHEMBL2937126 | 0.83 | RAB9A (0.67) | NPC1TP53RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1879873-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK Holdings Co., Ltd. (KR) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006112685-A1 | NEUROTHERAPEUTIC AZOLE COMPOUNDS | SK HOLDINGS CO., LTD. (KR) | 2006-10-26 | — | — | WO | disclosed |