Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2B | P41595 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14567623 | 1.00 | CYP1A2 (0.40) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL14379767 | 0.85 | TSHR (0.44) | CYP1A2HSD17B10TSHRHTR2AHTR2C | |
| SCHEMBL15630930 | 0.79 | HSD17B10 (0.43) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL5969960 | 0.79 | HSD17B10 (0.43) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL5969962 | 0.79 | HSD17B10 (0.43) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL5969963 | 0.79 | HSD17B10 (0.43) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL5969854 | 0.78 | HSD17B10 (0.42) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL5969851 | 0.78 | HSD17B10 (0.42) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL7739986 | 0.74 | CYP1A2 (0.39) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR | |
| SCHEMBL8503094 | 0.72 | PTGDR2 (0.45) | CYP1A2HSD17B10CYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1383733-B1 | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PROD INC (US) | 2008-03-05 | — | — | EP | disclosed |
| US-7285686-B2 | Process for the preparation of 1,3-substituted indenes | PFIZER INC (US) | 2007-10-23 | — | — | US | disclosed |
| US-7205300-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2007-04-17 | — | — | US | disclosed |
| US-20070066827-A1 | Process for the preparation of aryl fused polycyclic lactams | PFIZER INC. | 2007-03-22 | — | — | US | disclosed |
| US-7186870-B2 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds | PFIZER INC (US) | 2007-03-06 | — | — | US | disclosed |
| US-7144882-B2 | Aryl fused azapolycyclic compounds | PFIZER INC (US) | 2006-12-05 | — | — | US | disclosed |
| US-7091372-B2 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds | PFIZER INC (US) | 2006-08-15 | — | — | US | disclosed |
| EP-1259489-B1 | ARYL FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PROD INC (US) | 2006-06-07 | — | — | EP | disclosed |
| US-20060079707-A1 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds | PFIZER INC | 2006-04-13 | — | — | US | disclosed |
| EP-1619192-A2 | Aryl fused azapolycyclic compounds | Pfizer Products Inc. (US) | 2006-01-25 | — | — | EP | disclosed |
| EP-1587794-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | Pfizer Products Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| EP-1567483-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES | Pfizer Products Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20050004379-A1 | Process for the preparation of 1,3-substituted indenes | PFIZER INC | 2005-01-06 | — | — | US | disclosed |
| WO-2004063164-A1 | PROCESS FOR THE PREPARATION OF ARYL FUSED POLYCYCLIC LACTAMS | PFIZER PRODUCTS INC. (US) | 2004-07-29 | — | — | WO | disclosed |
| WO-2004048318-A1 | IMPROVED PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES | PFIZER PRODUCTS INC. (US) | 2004-06-10 | — | — | WO | disclosed |
| EP-1383733-A2 | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS | Pfizer Products Inc. (US) | 2004-01-28 | — | — | EP | disclosed |
| US-6605610-B1 | Reducing nicotine addiction; treating neurological and psychological disorders | PFIZER INC | 2003-08-12 | — | — | US | disclosed |
| US-20030130260-A1 | Aryl fused azapolycyclic compounds | COE JOTHAM WADSWORTH (US) | 2003-07-10 | — | — | US | disclosed |
| US-20030060624-A1 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic componunds | PFIZER INC. | 2003-03-27 | — | — | US | disclosed |
| WO-2002085843-A2 | PROCESS FOR THE PREPARATION OF 1,3-SUBSTITUTED INDENES AND ARYL-FUSED AZAPOLYCYCLIC COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2002-10-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004379-A1 | Process for the preparation of 1,3-substituted indenes | NISCH, DHPS, INA | CYP1A2 13/4885HSD17B10 1299/4885CYP3A4 28/4885 |
| US-20030130260-A1 | Aryl fused azapolycyclic compounds | GRIN2C, GRIN2A, GRIN3A | CYP1A2 10/4885HSD17B10 790/4885CYP3A4 80/4885 |
| US-20060079707-A1 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic compounds | CYP1B1, AZI2, CYP1A1 | CYP1A2 5/4885HSD17B10 1502/4885CYP3A4 25/4885 |
| US-20070066827-A1 | Process for the preparation of aryl fused polycyclic lactams | PAICS, GRIN2C, FDPS | CYP1A2 165/4885HSD17B10 1619/4885CYP3A4 152/4885 |
| US-20030060624-A1 | Process for the preparation of 1,3-substituted indenes and aryl-fused azapolycyclic componunds | INTS6, CYP1B1, CYP1A2 | CYP1A2 3/4885HSD17B10 1110/4885CYP3A4 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.