Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 5/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.64 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.64 |
| ▸ | VCP | P55072 | 2/20 | 0.64 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | CFTR | P13569 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156291 | 0.97 | MEN1 (0.66) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL14458492 | 0.89 | PTGS2 (0.76) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL208192 | 0.89 | ALOX5 (0.72) | MEN1KMT2AMAPTALOX5VCP | |
| SCHEMBL1885333 | 0.89 | ESR1 (0.72) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL205976 | 0.88 | ALOX5 (0.80) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL12297226 | 0.87 | MEN1 (0.69) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL205448 | 0.86 | ALOX5 (0.65) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL26126062 | 0.86 | ALOX5 (0.85) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL12297742 | 0.85 | MEN1 (0.80) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL12298053 | 0.85 | MEN1 (0.73) | MEN1KMT2ASMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192595-A1 | THIAZOLE DERIVATIVES AND METHODS OF USING THE SAME | Arkansas State University - Jonesboro (US) | 2023-10-05 | — | — | WO | disclosed |
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | IMPINJ, INC. | 2008-08-21 | — | — | US | disclosed |
| US-7381736-B2 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1841749-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | Metabasis Therapeutics, Inc. (US) | 2007-10-10 | — | — | EP | disclosed |
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-08-31 | — | — | US | disclosed |
| WO-2006028970-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | PTPN1, PTPN5, PTPN18 | MEN1 2838/4885KMT2A 1604/4885SMN1; SMN2 4199/4885 |
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | PTPN1, PTPN5, PTPN18 | MEN1 2838/4885KMT2A 1604/4885SMN1; SMN2 4199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.