Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.77 |
| ▸ | GAA | P10253 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | GLA | P06280 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.64 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13709155 | 0.87 | KMT2A (0.66) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL3595597 | 0.86 | HTT (0.70) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL5222691 | 0.84 | ALDH1A1 (0.70) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| Methyl Alcohol SCHEMBL4957272 | 0.84 | GAA (0.73) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL995085 | 0.84 | GAA (0.77) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL1291197 | 0.83 | TRPV1 (0.66) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL4958310 | 0.82 | GAA (0.71) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL27657640 | 0.82 | GAA (0.71) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL94829 | 0.82 | GAA (0.71) | ALDH1A1SMN1; SMN2GAARAB9ALMNA | |
| SCHEMBL4958300 | 0.82 | GAA (0.71) | ALDH1A1SMN1; SMN2GAARAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008094909-A2 | QUINAZOLINONE AND FUSED PYRIMIDINONE COMPOUNDS AND THEIR USE IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-08-07 | — | — | WO | disclosed |