Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 17/20 | 0.50 |
| ▸ | AKR1C2 | P52895 | 17/20 | 0.50 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13714204 | 0.87 | AKR1C3 (0.51) | PKMAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL8482490 | 0.86 | ACE2 (0.50) | PKMACE2 | |
| SCHEMBL8483426 | 0.81 | KDM4E (0.47) | CDK2 | |
| SCHEMBL6883303 | 0.81 | HSD17B10 (0.51) | PKMAKR1C3AKR1C2AKR1B10AKR1B1 | |
| SCHEMBL11621722 | 0.81 | AKR1C3 (0.47) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL18073734 | 0.80 | PKM (0.71) | PKMACE2 | |
| SCHEMBL11620041 | 0.80 | HPGD (0.47) | ACE2 | |
| SCHEMBL4955562 | 0.79 | PTPN1 (0.46) | PKMACE2 | |
| SCHEMBL11619384 | 0.79 | KDM4E (0.54) | AKR1C3 | |
| SCHEMBL5066588 | 0.78 | AKR1C3 (0.44) | PKMAKR1C3AKR1C2AKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | IMPINJ, INC. | 2008-08-21 | — | — | US | disclosed |
| US-7381736-B2 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. (US) | 2008-06-03 | — | — | US | disclosed |
| EP-1841749-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | Metabasis Therapeutics, Inc. (US) | 2007-10-10 | — | — | EP | disclosed |
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2006-08-31 | — | — | US | disclosed |
| WO-2006028970-A1 | DERIVATIVES OF THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | CENGENT THERAPEUTICS, INC. (US) | 2006-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060194768-A1 | Thiazole and thiadiazole inhibitors of tyrosine phosphatases | PTPN1, PTPN5, PTPN18 | PKM 1587/4885AKR1C3 4294/4885AKR1C2 4223/4885 |
| US-20080200371-A1 | THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES | PTPN1, PTPN5, PTPN18 | PKM 1587/4885AKR1C3 4294/4885AKR1C2 4223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.