Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.32 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4099713 | 0.90 | PGR (0.42) | PTGDR2KDM4EALDH1A1LMNAPGR | |
| SCHEMBL4102883 | 0.88 | PGR (0.44) | PTGDR2KDM4EALDH1A1LMNAPGR | |
| SCHEMBL5226673 | 0.86 | KCNH2 (0.47) | PTGDR2ALOX15PGRKCNH2 | |
| SCHEMBL4104516 | 0.85 | KCNH2 (0.36) | KDM4EALDH1A1LMNAKCNH2USP2 | |
| SCHEMBL4112540 | 0.84 | PGR (0.38) | KDM4EALDH1A1LMNAPGRKCNH2 | |
| SCHEMBL4654589 | 0.82 | PGR (0.41) | KDM4EALDH1A1LMNAPGRKCNH2 | |
| SCHEMBL4118214 | 0.82 | PGR (0.52) | PTGDR2ALOX15KDM4ELMNAPGR | |
| SCHEMBL4959580 | 0.81 | ALDH1A1 (0.44) | ALOX15KDM4EALDH1A1LMNAHPGD | |
| SCHEMBL4102616 | 0.81 | PGR (0.39) | KDM4EALDH1A1LMNAPGRKCNH2 | |
| SCHEMBL4810598 | 0.81 | PTGDR2 (0.45) | PTGDR2ALOX15KDM4EALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874732-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006111856-A1 | PYRAZOLE DERIVATIVES AS PROGESTERONE RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 2006-10-26 | — | — | WO | disclosed |