Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28984809 | 0.86 | HPGD (0.58) | HPGDALOX12RAB9ANPC1GAA | |
| SCHEMBL9979348 | 0.84 | HPGD (0.60) | HPGDALOX12POLBRAB9ANPC1 | |
| SCHEMBL9978909 | 0.83 | HPGD (0.58) | HPGDALOX12RAB9ANPC1GAA | |
| SCHEMBL6255583 | 0.83 | P2RX7 (0.72) | HPGDALOX12RAB9ANPC1ALDH1A1 | |
| SCHEMBL5923731 | 0.83 | P2RX7 (0.72) | HPGDALOX12POLBRAB9ANPC1 | |
| SCHEMBL2005846 | 0.83 | RAB9A (0.73) | HPGDALOX12POLBRAB9ANPC1 | |
| SCHEMBL29528561 | 0.83 | RAB9A (0.73) | HPGDALOX12POLBRAB9ANPC1 | |
| SCHEMBL27713876 | 0.82 | POLB (0.59) | HPGDPOLBRAB9AGAAALDH1A1 | |
| SCHEMBL10582815 | 0.81 | HPGD (0.53) | HPGDALOX12RAB9ANPC1ALDH1A1 | |
| SCHEMBL24485241 | 0.81 | POLB (0.57) | HPGDPOLBRAB9AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966176-A1 | HETEROCYCLIC GABA-B MODULATORS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | claimed |
| WO-2007073296-A1 | HETEROCYCLIC GABA-B MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | claimed |