Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5074408 | 0.89 | L3MBTL1 (0.62) | L3MBTL1KDM4ENPSR1ALDH1A1HPGD | |
| SCHEMBL4957699 | 0.73 | L3MBTL1 (0.60) | POLBL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL14522815 | 0.72 | TP53 (0.48) | L3MBTL1NPSR1TSHRMAPTTP53 | |
| SCHEMBL4960279 | 0.71 | L3MBTL1 (0.58) | POLBL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL11013240 | 0.69 | HPGD (0.75) | POLBL3MBTL1KDM4EALDH1A1HPGD | |
| SCHEMBL7491132 | 0.68 | NPC1 (0.62) | POLBL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL30606873 | 0.68 | NPC1 (0.62) | POLBL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL30606872 | 0.68 | NPC1 (0.62) | POLBL3MBTL1KDM4ENPSR1ALDH1A1 | |
| SCHEMBL13779304 | 0.68 | NPC1 (1.00) | L3MBTL1KDM4ENPSR1ALDH1A1HPGD | |
| SCHEMBL4896320 | 0.67 | L3MBTL1 (0.54) | L3MBTL1KDM4ENPSR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966176-A1 | HETEROCYCLIC GABA-B MODULATORS | AstraZeneca AB (SE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007073296-A1 | HETEROCYCLIC GABA-B MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | disclosed |