Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL613617 | 1.00 | KMT2A (0.47) | KMT2APOLBMEN1ALDH1A1NPC1 | |
| SCHEMBL4962503 | 0.90 | KMT2A (0.51) | KMT2APOLBMEN1NPC1RAB9A | |
| SCHEMBL4962513 | 0.90 | KMT2A (0.51) | KMT2APOLBMEN1NPC1RAB9A | |
| SCHEMBL613039 | 0.88 | USP30 (0.48) | ALDH1A1GAATSHRHSD17B10HPGD | |
| SCHEMBL612692 | 0.87 | GPBAR1 (0.49) | KMT2APOLBMEN1GAATSHR | |
| SCHEMBL4962181 | 0.87 | GPBAR1 (0.49) | KMT2APOLBMEN1GAATSHR | |
| SCHEMBL613084 | 0.86 | RAB9A (0.48) | KMT2APOLBMEN1ALDH1A1NPC1 | |
| SCHEMBL27665014 | 0.86 | RAB9A (0.48) | KMT2APOLBMEN1ALDH1A1NPC1 | |
| SCHEMBL612641 | 0.84 | RET (0.54) | — | |
| SCHEMBL613561 | 0.84 | NPC1 (0.49) | KMT2ANPC1RAB9AGAATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758580-A4 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORP (US) | 2008-01-16 | — | — | EP | claimed |
| CN-1993128-A | N-substituted piperidines and their use as pharmaceuticals | INCYTE CORP (US) | 2007-07-04 | — | — | CN | claimed |
| EP-1758580-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2006012226-A2 | N-SUBSTITUTED PIPERIDINES AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-02-02 | — | — | WO | claimed |
| CN-1993128-A | N-substituted piperidines and their use as pharmaceuticals | INCYTE CORP (US) | 2007-07-04 | — | — | CN | disclosed |