Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.62 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.62 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1241103 | 0.96 | HRH3 (0.68) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL6627983 | 0.94 | HRH3 (0.71) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL2730391 | 0.91 | SIGMAR1 (0.57) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL1239240 | 0.84 | SIGMAR1 (0.57) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL2326201 | 0.84 | LTA4H (0.64) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL578554 | 0.82 | SIGMAR1 (0.60) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL3657323 | 0.82 | KCNH2 (0.59) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL7491748 | 0.81 | MAPT (0.50) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 | |
| SCHEMBL24495209 | 0.80 | SPHK1 (0.63) | HRH3SIGMAR1 | |
| SCHEMBL16345749 | 0.80 | SIGMAR1 (0.45) | HRH3L3MBTL1L3MBTL3MBTD1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945628-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007040440-A1 | NEW PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY AS WELL AS THE USE OF PYRIMIDINE DERIVATIVES IN THE MANUFACTURE OF A MEDICAMENT FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER’S DISEASE | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |