Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1235217 | 0.91 | PIK3CG (0.55) | PIK3CGPIK3CAPIK3CDPIK3CBKMT2A | |
| SCHEMBL1234114 | 0.86 | KDM4E (0.58) | PIK3CGPIK3CAPIK3CDPIK3CBKDM4E | |
| SCHEMBL1234641 | 0.79 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CDPIK3CBKMT2A | |
| SCHEMBL8729490 | 0.79 | RORA (0.44) | PIK3CGPIK3CAPIK3CDPIK3CBKDM4E | |
| SCHEMBL1237747 | 0.78 | PIK3CG (0.53) | PIK3CGPIK3CAPIK3CDPIK3CBKMT2A | |
| SCHEMBL1234690 | 0.76 | PIK3CG (0.61) | PIK3CGPIK3CAPIK3CDPIK3CBPIK3C2A | |
| SCHEMBL1236872 | 0.74 | KMT2A (0.50) | PIK3CGPIK3CAPIK3CDPIK3CBKMT2A | |
| SCHEMBL1237761 | 0.73 | PIK3CG (0.48) | PIK3CGPIK3CAPIK3CDPIK3CBPOLB | |
| SCHEMBL1235063 | 0.73 | PIK3CD (0.65) | PIK3CGPIK3CAPIK3CDPIK3CBPIK3C2A | |
| SCHEMBL12713775 | 0.72 | PIK3CG (0.47) | PIK3CGPIK3CAPIK3CDPIK3CBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888573-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2008-02-20 | — | — | EP | disclosed |
| EP-1885716-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006125803-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006125807-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | disclosed |