Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UBE2M | P61081 | 10/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 10/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496366 | 0.93 | UBE2M (0.39) | UBE2MDCUN1D1SLC6A5LCKMAPK14 | |
| SCHEMBL496258 | 0.88 | SCN10A (0.38) | UBE2MDCUN1D1LCKMAPK14MEN1 | |
| SCHEMBL10129624 | 0.84 | TRPV4 (0.40) | TRPV4TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL10129642 | 0.81 | FLT3 (0.47) | TRPV4TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL10129645 | 0.81 | FLT3 (0.47) | TRPV4TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL496209 | 0.79 | TRPV1 (0.39) | TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL496026 | 0.79 | TRPV1 (0.39) | TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL496111 | 0.79 | TRPV1 (0.39) | TRPV1RXFP1SCN10ASCN8A | |
| Hydrochloric Acid SCHEMBL496005 | 0.78 | SCN8A (0.39) | TRPV1RXFP1SCN10ASCN8A | |
| SCHEMBL495747 | 0.78 | SCN10A (0.40) | TRPV1RXFP1SCN10ASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1955697-B1 | 2-AMINOBENZAMIDE DERIVATIVES AS VANILLOID RECEPTOR 1 (VR1) INHIBITORS USEFUL FOR THE TREATMENT OF PAIN OR BLADDER FUNCTION DISORDER | ASTELLAS PHARMA INC (JP) | 2012-05-02 | — | — | EP | claimed |
| US-8106190-B2 | 2-aminobenzamide derivatives | ASTELLAS PHARMA INC. (JP) | 2012-01-31 | — | — | US | claimed |