Aminothiazole

Aminothiazole

SCHEMBL4962431

Nc1nccs1.Nc1nccs1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 1.00
TSHR P16473 1/20 1.00
NOS1 P29475 1/20 1.00
HSD17B10 Q99714 1/20 1.00
FBP1 P09467 3/20 0.46
PDK1 Q15118 1/20 0.46
HSP90AA1 P07900 2/20 0.41
PDPK1 O15530 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.38
ADORA2A P29274 2/20 0.38
ADORA1 P30542 1/20 0.36
CHEK1 O14757 1/20 0.36
AURKA O14965 1/20 0.36
DAPK3 O43293 1/20 0.36
JAK2 O60674 1/20 0.36
MAP4K4 O95819 1/20 0.36
ABL1 P00519 1/20 0.36
NTRK1 P04629 1/20 0.36
LCK P06239 1/20 0.36
FYN P06241 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Aminothiazole SCHEMBL1136755 1.00
Aminothiazole SCHEMBL10428703 1.00
Aminothiazole SCHEMBL7401 1.00
Aminothiazole SCHEMBL11884793 0.97
Aminothiazole SCHEMBL5781624 0.97
Aminothiazole SCHEMBL7473421 0.97
Aminothiazole SCHEMBL1641818 0.97
Aminothiazole SCHEMBL29012817 0.97
Aminothiazole SCHEMBL2350289 0.97
Aminothiazole SCHEMBL7469112 0.97

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102617620-B One class contains antibiosis rare earth ternary complexes of heterocyclic ligand and its preparation method and application SHANGHAI NORMAL UNIVERSITY (CN) 2015-12-16 CN disclosed
CN-102617613-B A kind of high-efficiency antimicrobial copper ternary complex containing heterocyclic ligand and its preparation method and application SHANGHAI NORMAL UNIVERSITY (CN) 2015-08-19 CN disclosed
EP-1877391-A1 PRO-DRUGS OF N-THIAZOL-2YL-BENZAMIDE DERIVATIVES H. Lundbeck A/S (DK) 2008-01-16 EP disclosed
WO-2006114093-A1 PRO-DRUGS OF N-THIAZOL-2YL-BENZAMIDE DERIVATIVES H. LUNDBECK A/S (DK) 2006-11-02 WO disclosed